AnalysisScienceSeptember 23, 2026

Graph neural network maps Alzheimer's phenotypes in 584 brains

PASCode scored ~1.5 million phenotype-associated cells from single-nucleus RNA sequencing of 584 donors, spanning 27 brain cell subclasses. It flagged microglia subpopulations and reactive astrocyte subtypes tied to cognitive resilience, and is released as an open-source tool with pretrained models.

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