Microsoft's ThinkingBox turns database grading into RL rewards for agents

A Reddit user with 48GB VRAM (2x RTX 3090) and 48GB DDR4 asks whether 128GB DDR4 would let them run Deepseek V4.1 1017 and GLM 5.3 Flash at low quants at ~20 tokens/sec. No benchmarks or answers are included in the post.

Anthropic is inviting principal investigators at academic institutions, nonprofits, and government labs to apply for 8–12 week projects using Claude on causal human biology, structural and computational molecular biology, medicinal chemistry, drug discovery, and clinical science. Anthropic runs its models and harnesses at no cost, and outputs are published with open-source data and code.

In a collaboration with Theorem, Claude proved security properties at the RISC-V assembly level in over 100 real-world open-source libraries — described as the first large-scale AI formal-verification effort on production software at that level. Claude also found bugs that had survived trillions of test runs.

Nightly build v0.26.0-nightly.20261022.bf66a26c97 adds daemon token persistence and a release fix covering every spawned vendored binary in the tarball exec-bit gate. Also includes managed-agent test changes reusing a same-key cancel.

The bundled dataviz skill now accepts APCA as a text-contrast measure while keeping WCAG 2 ratios for AA conformance, and adds an apca(text, background) function to its palette validator. claude ultrareview now requires workspace trust, with scripts passing --trust-workspace or setting CLAUDE_CODE_DISABLE_ULTRAREVIEW_TRUST_CHECK=1.

Claude Models on Google Cloud (Anthropic managed) gives customers the full Claude API, including Managed Agents, code execution and Opus 5.5 fast mode, with new features shipping same-day as the native platform. Access uses existing Google Cloud IAM credentials, bills on one Google Cloud invoice and draws down existing commitments; US and Global endpoints only.

The round is led by Coatue and UAE investors and would make OpenAI the most valuable private company ever, topping its $852B post-money mark from March. CNBC reports the UAE funding could come with a deal for more OpenAI computing capacity there.